The Internet can be a fantastic source of high-quality information, but it is also a place where anyone can say anything they chose about any subject. There is no fact-checking for blog posts, and the ignorant and uninformed have the same right to speak their mind as the world’s experts, on any topic. So use a little common sense. If you want the most reliable medical information, it is all at your disposal at the PubMed database website, provided by the National Library of Medicine. Just go to PubMed.gov and type in your search parameters. Type “Protandim” and hit Search, and you will see all the peer-reviewed studies that have been published so far. Click on any publication that turns up, and you will see a summary (abstract) of the study, and you may have access to the full paper as a PDF file. Type in “oxidative stress cancer” and you will find more than 8,300 papers on the topic. (You may need a Ph.D. to fully understand the papers, but you will be surprised at how much you can understand from a well-written abstract.)

To the best of our knowledge, Protandim is the only supplement in the world clinically proven (in a peer-reviewed, human clinical study) to reduce aging factors by an average of 40 percent. Protandim has been granted four patents and is the subject of more than 20 independent clinical studies at the present time.

This patented antioxidant therapy is many times more powerful than red wine, oranges, blueberries, juices or other popular antioxidant supplements. Protandim works by increasing the body’s natural antioxidant protection at the cellular level, triggering cells to produce naturally occurring protective antioxidant enzymes such as superoxide dismutase (SOD), catalase, and the enzymes involved in glutathione synthesis and metabolism.

Protandim’s actions result from its ability to activate the transcription factor known as Nrf2. Protandim contains five ingredients that are known to scientists as Nrf2 activators. Nrf2 is a protein messenger contained in every cell of the body that sends information to the cell’s DNA. That DNA consists of about 25,000 genes and the products of those genes make you who you are and what you are. They’re unique for each person. DNA is what makes you a human being, what gives you your personality, what gives you your physical traits.

When this protein messenger called Nrf2 is activated, it enters the nucleus of every cell and it turns on several hundred of these 25,000 genes. And the genes that it turns on, or turns up, are known collectively as “survival genes.” What is a survival gene? These genes enable cells to survive in the face of several different kinds of stress, especially oxidative stress, which is due to the overproduction of free radicals and other oxidants.

Nrf2 also affects another hundred or so genes by turning them down, not up. Included in these genes are pro-inflammatory and pro-fibrotic genes.

Inflammation accompanies many different disease processes. Everyone is familiar with inflammatory diseases such as arthritis, but anytime you suffer traumatic injuries, sprain your ankle or bruise yourself, there is swelling, pain and redness that characterize inflammation. The process of inflammation is designed, in part, to prevent infection. One of the ways your body prevents infection is to kill invading microorganisms by intentionally making toxic free radicals. Thus, the pain, redness and swelling in a cut are not so much from infection, but from inflammation as your body responds to the possibilities of an infection.

What are Pro-Fibrotic genes? Following inflammation in many kinds of diseases or traumatic injury is a process of scar tissue formation that scientists refer to as “fibrosis.” A number of genes turn on that process. And while fibrosis can be a good thing if you’re healing from a cut, it is a bad thing in many other diseases. For example, many older people die each year from heart failure–the failure of the pumping action of the heart due to this process of fibrosis. This is quite a different process from “hardening of the arteries” or atherosclerosis, which leads to heart attacks and strokes.

So, Protandim, as a Nrf2 activator, activates survival genes, such as antioxidant genes, that keep us safe from free radicals and oxidants. It also turns down genes that perpetuate inflammation and genes that encourage slow, progressive fibrosis to take place. Together, these actions provide a remarkable promise of protection from many kinds of age-related diseases.

Protandim is among the very first of the products that are appearing, and will appear, as Nrf2 activators. It is, as far as we know, the first potent commercially available Nrf2 activator.

Protandim is different from other antioxidant supplements because it is among the very first of the products that are appearing and will appear as Nrf2 activators. As far as we know, Protandim is the first potent commercially available Nrf2 activator.

Nrf2 is a protein messenger contained in every cell of the body that sends information to the cell’s DNA. When this protein messenger called Nrf2 is activated, it enters the nucleus of every cell and turns on several hundred of these 25,000 genes, collectively known as survival genes. Protandim, as a Nrf2 activator, activates survival genes, such as antioxidant genes, that keep us safe from free radicals and oxidants and also turns down genes that perpetuate inflammation and genes that encourage slow, progressive fibrosis to occur. Together, these actions provide a remarkable promise of protection from many kinds of age-related diseases.

Protandim is different from other antioxidant supplements in the way it works. Instead of providing the body with additional dietary antioxidants (regular supplements fall into this category and are commonly called consumable or “direct” antioxidants), Protandim works from within your body, signaling it to boost its own production of numerous antioxidant enzymes (including the well-known ones—SOD and catalase) that already exist at the cellular level to help fight free radicals and cellular aging. This is why Protandim is significantly more effective than any other antioxidant on the market today; your body is actually producing the antioxidant power. But Protandim goes far beyond antioxidant protection; it activates hundreds of “survival genes” that help your body survive many kinds of stress.

Vitamin C is not a Nrf2 Activator. Vitamin E and CoQ10 are very, very weak activators at high doses and in cultured cells. It’s not clear whether these compounds have practical Nrf2 activating activity in intact animals, or whether sufficiently high concentrations could be reached.

Many people mistakenly believe their antioxidant needs are fulfilled by eating blueberries, drinking expensive “miracle juices” and applying antioxidant facial creams. What they don’t realize is that their daily antioxidant needs cannot be fulfilled by consuming any amount of blueberries, dark chocolate or red wine. Effective antioxidant protection absolutely requires adequate production of the body’s own antioxidant enzymes.

As much fun as it would be to eat 15 pounds of chocolate daily, it would be impossible. Protandim is the only solution available to provide the necessary amount of antioxidants. Protandim, an all-natural dietary supplement that holds four patents, has been proven to decrease oxidative stress by an average of 40 percent and has been peer-reviewed in a published, human clinical study.

Nationally recognized anti-aging expert Dr. Joe McCord explains, “Researchers and scientists agree that aging is the result of cellular deterioration caused by free radicals, which are rogue molecules. It is impossible to avoid free radicals because the food you eat and the air you breathe, as well as stress or even vigorous exercise, can stimulate cells to produce destructive free radicals in staggering numbers. With each year, a person’s body becomes less effective at fighting free radicals. It’s a vicious cycle, programmed into genes, which results in aging, disease and eventually death. A person’s body fights free radicals by producing its own antioxidant enzymes. But as we grow older, our bodies produce more free radicals and fewer of these antioxidant enzymes to fight the battle of aging. That’s where Protandim plays a critical role. Protandim boosts the body’s own production of antioxidant enzymes at the cellular level with enough neutralizing capacity to eliminate the age-related increase in free radical damage.”

The science and clinical proof behind Protandim is impressive. In fact, a peer-reviewed, human clinical study showed that after only 30 days of taking Protandim, free radicals decreased an average of 40 percent, slowing the progressive aging factors to the level of a 20-year-old.
View the study.

Since the initial peer-reviewed clinical and laboratory studies were published in 2006 and 2009, Protandim has been the subject of more than 20 independent studies at various university and research facilities around the world. Additional peer-reviewed studies have been published. These include: an in vivo study using mice to examine the tumor prevention capabilities of Protandim conducted at Louisiana State University; an in vivo study exploring pulmonary hypertension and subsequent right heart failure conducted at Virginia Commonwealth University; an in vivo study examining the affects of Protandim in mice with muscular dystrophy conducted at Massachusetts General Hospital, Harvard Medical School and at the University of Colorado; and a study conducted at Louisiana State University, probing Protandim’s ability to modulate the relationship between superoxide dismutase and tumor suppressor p53.

The third study, completed at Louisiana State University (LSU) and sponsored by the Skin Cancer Foundation, was published in the journal “PloS ONE,” an international, peer-reviewed, open access journal published by the Public Library of Science. This study, entitled “Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin Carcinogenesis as a Model,” investigated whether Protandim could suppress tumor formation in mice through a dietary approach. At the end of a two-stage skin carcinogenesis, the mice on the Protandim-supplemented diet showed a reduction in both skin tumor incidence and multiplicity by 33 percent and 57 percent, respectively compared to those on a basal diet. The study concluded that an induction of antioxidant enzymes by Protandim may serve as a practical and potent approach for cancer prevention.
View the sudy.

The fourth study, from Virginia Commonwealth University, was published in “Circulation,” a prestigious journal of the American Heart Association. This study, entitled “Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure,” investigated the ability of Protandim to protect the heart in a laboratory model of pulmonary hypertension in rats. Finding that Protandim also prevented the death of heart cells and significantly lowered osteopontin (OPN-1) levels by more than 50 percent, the researchers found the ability of Protandim to effectively activate the transcription factor Nrf2, a signal to the cell’s DNA to increase expression of a network of antioxidant, anti-inflammatory and anti-fibrotic genes.
View the study.

The fifth study, “The Dietary Supplement Protandim Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress in Muscular Dystrophy Mdx Mice,” was published in the “Journal of Dietary Supplements.” It demonstrated Protandim’s ability to decrease the body’s production of harmful gene products such as osteopontin. This was in addition to its proven ability to increase production of the body’s Nrf2-regulated protective genes, sometimes referred to as “survival genes.” It also concluded that Protandim improves markers of fibrosis in a model of Duchenne muscular dystrophy (DMD). The study was performed by Dr. Brian Tseng and his colleagues at Massachusetts General Hospital, Harvard Medical School and the University of Colorado-Denver.
View the study.

A sixth study, titled “The Chemopreventive Effects of Protandim: Modulation of p53 Mitochondrial Translocation and Apoptosis during Skin Carcinogenesis,” was conducted by researchers at Louisiana State University and published in the scientific journal “PloS ONE.” The researchers previously reported on the ability of Protandim to reduce both the incidence and the number of skin cancers in mice (see above). That ability was previously demonstrated by the authors in a study involving a mouse two-stage model of chemically induced skin cancer. Protandim had been shown in earlier studies to activate the transcription factor Nrf2, a signal to the cell’s DNA to regulate a network of protective genes. This new study further investigated Protandim’s ability to increase production of the body’s Nrf2-regulated protective genes, sometime referred to as “survival genes.” This study examined the biochemical mechanisms that underlie the ability of Protandim to suppress tumors in mice.
View the study.

The Protandim product is currently the subject of more than 20 independent scientific studies at various universities and research facilities. The nature and stages of the studies vary, as some are still in planning stages, while other studies are nearing completion. Universities and institutions conducting research include the University of Colorado; Colorado State University; the University of Utah; Northwestern University; Duke University; Louisiana State University; Ohio State University; Vanderbilt University; Glamorgan University, Wales; Sahlgrenska University Hospital, Sweden; Harvard University; and the Mexican Institute of Social Security, Mexico City. The various studies deal with the alleviation of oxidative stress under the following conditions: altitude sickness, non-alcoholic steatohepatitis, lung antioxidant status in withdrawing alcoholics, autonomic physiology and aging, skin cancer, multiple sclerosis, pulmonary hypertension, heart disease, coronary artery bypass graft failure, asthma, Duchenne muscular dystrophy and hearing loss.

Milk Thistle Extract containing 80% silymarin, Bacopa Extract containing 45% bacosides, Ashwagandaha root powder, Green Tea Extract containing 98% polyphenols, Tumeric Extract containing 95% curcumin.

No, they are not “certified” organic. However, they are all harvested in their natural pure environment.

Ashwahangha – India, Bacopa – India, Green Tea- China, Milk Thistle – China, Tumeric – India.

Yes, the raw materials are tested for: Pesticides/Herbicides; Heavy Metals; Active Compound in 5 Active Ingredients (for example, we test Bacopa for Bacosides and Turmeric for Curcumonoids); All Microbial tests; and, Efficacy/Bioavailability.

No, there are no dyes or food colorings in Protandim. One of the active ingredients, curcumin, is intensely yellow.

No, the blend of ingredients and their special formulation is unique to Protandim and holds four patents. The combination of ingredients creates a synergy that has been studied and proven to provide much more antioxidant power than any food or conventional supplements. This scientific peer-reviewed study was published in the journal “Free Radical Biology and Medicine” and it also clearly shows Protandim produces a 300 percent increase in glutathione, which is a key antioxidant and anti-aging factor.

No. The estrogenic effects of silymarin are well studied. Below is the abstract of a study that found no binding of silymarin to the estrogen receptor alpha (ERalpha). Binding to ERalpha would be a cause for concern in estrogen-sensitive breast or uterine cancer patients. Silymarin is an agonist (positive effector) for the ERbeta receptor, whereby it can positively affect bone density.

Reference: Seidlova-Wuttke, D.; Becker, T.; Christoffel, V.; Jarry, H.; Wuttke, W. Silymarin is a selective estrogen receptor beta (ERbeta) agonist and has estrogenic effects in the metaphysis of the femur but no or anti-estrogenic effects in the uterus of ovariectomized (ovx) rats. J. Steroid Biochem. Mol. Biol. 86:179-188; 2003.

Other ingredients: Calcium Carbonate, Croscarmellos Sodium, Dicalcium Phosphate, Magnesium Stearate, Microcrystalline Cellulose, Modified Cellulose, Silica, Stearic Acid. The cellulose (plant fiber) and other excipients allow the ingredients to hold together when pressed to form a caplet. Magnesium stearate is a natural lubricant that allows the caplet to be released from the dye. Another agent keeps the ingredients dry. These same excipients are found in most pressed tablets and caplets.

Protandim contains less than 4 mg. of caffeine. (By comparison, a Starbuck’s coffee may contain up to 150 mg. and “caffeine-free” coffee may contain 4-7 mg.)

Yes, we are “Standardized.”

Yes, to the best of our knowledge we meet or exceed the Current Good Manufacturing Practices {“cGMPs”) for Nutritional Supplements.

Also, all raw materials are validated before they are purchased. This means we test all inbound raw materials for quality and purity.

Also, Protandim is subject to existing dietary supplement laws, such as the Dietary Supplement Health and Education Act, including adverse event reporting requirements. LifeVantage has established the safety and purity of all its ingredients through independent laboratory testing.

No, Protandim is not “Pharma” (Pharmaceutical) Grade. Protandim is a dietary supplement, not a drug.

Yes, the raw ingredients are pressed into tablet form. Our tablets are pressed without any extraneous heat. The only heat that results from the process is from natural friction. There is no raw material degradation from the process. This is considered “cold” pressed or “soft” pressed.

Yes. We do not expect there to be any side-effects for the typical consumer who consumes Protandim. Some individuals have natural allergic responses to one or another of the ingredients, just as some people are allergic to pine pollen or penicillin. These allergic responses to Protandim generally appear as gastrointestinal disturbances (i.e., stomach ache, diarrhea, vomiting) or sometimes as a headache or rash on the hands or feet. The symptoms disappear if Protandim is discontinued, and so far none have required medical treatment. Some of those experiencing these side-effects or allergies have been able to continue with Protandim at a half dose. Others simply cannot take Protandim.

Any side-effect occurring within 10 minutes is unlikely due to Protandim. It may take an hour or two before the caplet dissolves and the gene induction effects of Protandim require many hours to begin.

Some Western diets are lacking in certain nutritional elements, so multivitamin supplementation may be beneficial for some people. You can discontinue supplementing with antioxidants, however, because Protandim is more effective at eliminating free radical damage than supplementation with conventional antioxidants.

Protandim is not recommended during chemotherapy or radiation therapy for cancer. Why not? Because chemotherapy and radiation therapy are designed to kill (cancer) cells by causing oxidative stress.

Also, Because Protandim may exacerbate certain autoimmune diseases, you should consult your physician before taking Protandim when dealing with such diseases or when taking immunosuppressive drugs following a transplanted organ received from another person. Again, why not in this case? Because the immune system is what helps fight off viruses, bacteria and other foreign objects. When you have just received an organ from another person this could be detected as a foreign object by your immune system which will reject and try to kill it, as it would an invading microorganism. In such circumstances, you physician may maintain your immune system in a suppressed state, to help avoid rejection.

Just like prescription drugs, the ingredients in many supplements are metabolized in the liver and excreted by the kidneys in the urine. The ingredients in Protandim, however, are primarily metabolized and excreted by the liver into the bile. This difference decreases the likelihood of Protandim interacting with other over-the-counter products or with prescription drugs. In fact, after years of public availability and use, we know of no significant drug interaction with Protandim.

Yes, people on Coumadin can take Protandim without interference. If they test their own clotting time, they should test a day or two after starting Protandim to make sure they don’t need an adjustment in Coumadin dosage. Also, as always, if there is a question, consult your doctor! Note: Surgeons recommend that ALL supplements be stopped before surgery – that is why this is on the label. (See “Prescription Drugs” above).

Yes. There is no known problem for Plavix users taking Protandim. (See “Prescription Drugs” above).

Yes. There is no reason Protandim would interfere with a pacemaker.

Many obstetricians recommend that women stop taking everything except what they prescribe. (See the warning label of the Protandim bottle). However, if your obstetrician approves Protandim, there is no known reason for concern.

No, the ability to absorb the ingredients is self-limiting, so after a certain point no more is absorbed.

No, there is no known mechanism whereby Protandim loses effectiveness over time. The formula has not been changed, and bioactivity is monitored to maintain consistent potency with regard to the activation of the Nrf2 transcription factor – the mechanism by which Protandim works.

The shelf life for Protandim is three years.

With food. First of all, there are no foods to avoid. Next, the active ingredients in Protandim are all fat soluble. Although it is not absolutely necessary, taking Protandim with a meal containing some fat allows the ingredients to be absorbed more efficiently.

No, although our five ingredients are not on the list of banned substances for professional athletes, we do not currently have such a certification.

There are many ways in which oxidative stress can be measured in the laboratory. TBARS was chosen because it has been the most widely used, with more than 8,000 published studies. These studies provide a valuable basis for comparison. TBARS reflect oxidative damage to polyunsaturated lipids, perhaps the most sensitive major class of biological molecules to free-radical damage.

To the best of our knowledge no commercial lab offers a T-BARS test. Why is this? First of all, because there is no “fix” for T-BARS other than Protandim and so it is not a priority. Next, it is a difficult test to perform outside of a research lab because the products are unstable and the samples have to be measured very quickly, a process that is difficult to do under commercial conditions. For these very reasons, the commercially offered T-BARS can be inconsistent and unreliable.